I stumbled across something I wrote about 6 years ago and I think it's still as pertinent as ever. I'm glad to say I heeded my own advice 2 years ago when I went off on my own.
There are a lot of people out there who just didn't get it and piss away their lives at some shitty job they hate; and to them I say this - Leave. Right now. Go write that book, go make that movie, go record that album, go on that roadtrip, go make that baby, go visit your college roommate, go call your mother, go learn how to fly/play golf/scuba dive/speak french, go work on that open source project, go to the beach and just sit there, go to San Francisco and remind yourself why you live here, go do SOMETHING that means something to you. Even if you just go on vacation, at least do it. You're not curing cancer, you're not creating world peace. Whatever you're working on, it can wait until tomorrow. Go home and spend some time with your family. Take a deep breath....and relax. It's not that important. You're all good people, and some of the smartest I have ever met in my life. Go make it happen.